-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, WyNhc+GbjEcd6tQ68vHGRocaHxLcc2XjHBc0knS8WZ/Zf+UPtksSg7TwFAKq+KBB cVo+u6bdgg8kdT6YCHDU3Q== 0000950005-01-000080.txt : 20010209 0000950005-01-000080.hdr.sgml : 20010209 ACCESSION NUMBER: 0000950005-01-000080 CONFORMED SUBMISSION TYPE: SC 13G PUBLIC DOCUMENT COUNT: 1 FILED AS OF DATE: 20010208 SUBJECT COMPANY: COMPANY DATA: COMPANY CONFORMED NAME: ONYX PHARMACEUTICALS INC CENTRAL INDEX KEY: 0001012140 STANDARD INDUSTRIAL CLASSIFICATION: BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836] IRS NUMBER: 943154463 STATE OF INCORPORATION: DE FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G SEC ACT: SEC FILE NUMBER: 005-45955 FILM NUMBER: 1528764 BUSINESS ADDRESS: STREET 1: 3031 RESEARCH DR STREET 2: BLDG A CITY: RICHMOND STATE: CA ZIP: 94806 BUSINESS PHONE: 5102229700 MAIL ADDRESS: STREET 1: 3031 RESEARCH DRIVE STREET 2: 3031 RESEARCH DRIVE CITY: RICHMOND STATE: CA ZIP: 94806 FILED BY: COMPANY DATA: COMPANY CONFORMED NAME: ALTA PARTNERS CENTRAL INDEX KEY: 0001060013 STANDARD INDUSTRIAL CLASSIFICATION: [] IRS NUMBER: 943238854 STATE OF INCORPORATION: CA FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: SC 13G BUSINESS ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 BUSINESS PHONE: 4153624022 MAIL ADDRESS: STREET 1: ONE EMBARCADERO CENTER STREET 2: STE 4050 CITY: SAN FRANCISCO STATE: CA ZIP: 94111 SC 13G 1 0001.txt SC 13G United States Securities and Exchange Commission Washington, D.C. 20549 Schedule 13G (Rule 13-d-102) Information statement pursuant to rules 13-d-1 and 13-d-2 Under the Securities Exchange Act of 1934 (Amendment No. 2) ONYX PHARMACEUTICALS, INC. ----------------------------------------- (Name of Issuer) Common Stock ----------------------------------------- (Title of Class of Securities) 683399109 ----------------------------------------- (CUSIP Number)
CUSIP No. 683399109 Page 2 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Partners - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization California - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person --- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A
CUSIP No.683399109 Page 3 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Partners, L.P. - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person ---- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A
CUSIP No. 683399109 Page 4 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta BioPharma Management Partners, LLC. - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person --- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A
CUSIP No. 683399109 Page 5 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Onyx Chase Partners (Alta Bio), LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group ---- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person N/A Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares--- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A
CUSIP No. 683399109 Page 6 of 17 pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta Embarcadero BioPharma Partners, LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization California - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person --- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) ---- Exit Filing (12) Type Of Reporting Person N/A
CUSIP No. 683399109 Page 7 of 17 pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alta/Chase BioPharma Management, LLC - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group ---- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization Delaware - ------------------------------------------------------------------------------------------------------------ Number Of Shares (5) Sole Voting Power See Item 4 Beneficially Owned By Each Reporting (6) Shared Voting Power N/A Person With (7) Sole Dispositive Power See Item 4 (8) Shared Dispositive Power N/A (9) Aggregate Amount Beneficially Owned By Each Reporting Person --- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares ---- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) ---- Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------
CUSIP No. 683399109 Page 8 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Jean Deleage - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person ---Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 683399109 Page 9 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Garrett Gruener - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person --- Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) --- Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 683399109 Page 10 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Daniel Janney - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person ----Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares ---- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 683399109 Page 11 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Alix Marduel - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group --- NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 683399109 Page 12 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Guy Nohra - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
CUSIP No. 683399109 Page 13 of 17 Pages - ------------------------------------------------------------------------------------------------------------ (1) Names of Reporting Persons. SS or I.R.S. Identification Nos. of Above Persons Marino Polestra - ------------------------------------------------------------------------------------------------------------ (2) Check The Appropriate Box If A Member Of A Group NOT APPLICABLE - ------------------------------------------------------------------------------------------------------------ (3) SEC Use Only - ------------------------------------------------------------------------------------------------------------ (4) Citizenship or Place of Organization United States - ------------------------------------------------------------------------------------------------------------ Please see Item 4 and Attachment A Number Of Shares (5) Sole Voting Power N/A Beneficially Owned By Each Reporting (6) Shared Voting Power See Item 4 Person With (7) Sole Dispositive Power N/A (8) Shared Dispositive Power See Item 4 (9) Aggregate Amount Beneficially Owned By Each Reporting Person Please see Item 4 and Attachment A (10) Check If The Aggregate Amount In Row (11) Excludes Certain Shares --- Not Applicable (11) Percent Of Class Represented By Amount In Row (11) Exit Filing (12) Type Of Reporting Person N/A - ------------------------------------------------------------------------------------------------------------ *SEE INSTRUCTION BEFORE FILLING OUT!
Item 1. (a) Name of Issuer: Onyx Pharmaceuticals, Inc. ("Issuer") (b) Address of Issuer's Principal Executive Offices: One Cambridge Center Cambridge, MA 02142 Item 2. (a) Name of Person Filing: Alta Partners ("AP") Alta BioPharma Partners, L.P. ("ABP") Alta BioPharma Management Partners, LLC. ("ABMP") Alta Embarcadero BioPharma Partners, LLC ("AEBP") Onyx Chase Partners (Alta Bio), LLC ("OCP") Alta/Chase BioPharma Management, LLC ("ACMP") Jean Deleage ("JD") Garrett Gruener ("GG") Dan Janney ("DJ") Alix Marduel ("AM") Guy Nohra ("GN") Marino Polestra ("MP") (b) Address of Principal Business Office: One Embarcadero Center, Suite 4050 San Francisco, CA 94111 (c) Citizenship/Place of Organization: Entities: AP - California ABP - Delaware ABMP Delaware AEBP California OPCP Delaware ACMP Delaware Individuals: JD United States GG United States DJ United States AM United States GN United States MP United States (d) Title of Class of Securities: Common Stock (e) CUSIP Number: 683399109 (f) Item 3. Not applicable. Item 4 Ownership.
NO LONGER A 5% SHAREHOLDER IN ONYX PHARMACEUTICALS, INC. Please see Item 4 and Attachment A - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- AP ABP ABMP AEBP OCP ACMP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 681,111 423,369 423,369 15,957 241,785 241,785 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 3.8% 2.4% 2.4% 0.09% 1.3% 1.3% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power 681,111 423,369 423,369 15,957 241,785 241,785 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power 681,111 423,369 423,369 15,957 241,785 241,785 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- JD GG DJ AM GN MP - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (a) Beneficial Ownership 681,111 681,111 681,111 681,111 681,111 681,111 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (b) Percentage of Class 3.8% 3.8% 3.8% 3.8% 3.8% 3.8% - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- (c) Sole Voting Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Voting Power 681,111 681,111 681,111 681,111 681,111 681,111 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Sole Dispositive Power -0- -0- -0- -0- -0- -0- - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- -------------- Shared Dispositive Power 681,111 681,111 681,111 681,111 681,111 681,111 - ------- ---------------------------- ----------- ----------- ------------ ----------- ------------- --------------
Item 5. Ownership of Five Percent or Less of a Class Exit Filing --- No longer 5% Shareholder. Item 6. Ownership of More than Five Percent on Behalf of Another Person Not applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company. Not applicable. Item 8. Identification and Classification of Members of the Group No reporting person is a member of a group as defined in Section 240.13d-1(b)(1)(ii)(H) of the Act. Item 9. Notice of Dissolution of Group Not applicable. Item 10. Certification Not Applicable EXHIBITS A: Joint Filing Statement Signature After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct. Date: February 2, 2001
Alta Partners Alta BioPharma Partners, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------- ------------------------------- Jean Deleage, President Alix Marduel, Managing Director Alta BioPharma Management Partners, LLC Alta Embarcadero BioPharma Partners, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------- ------------------------------- Alix Marduel, Member Jean Deleage, Member Onyx Chase Partners (Alta Bio), LLC Alta/Chase BioPharma Management, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------- ------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra ----------------------- ------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Marino Polestra ----------------------- ------------------------------- Garrett Gruener Marino Polestra /s/ Daniel Janney /s/ Alix Marduel Daniel Janney Alix Marduel
Exhibit A Agreement of Joint Filing We, the undersigned, hereby express our agreement that the attached Schedule 13G is filed on behalf of us. Date: February 2, 2001
Alta Partners Alta BioPharma Partners, L.P. By: Alta BioPharma Management Partners, LLC By: /s/ Jean Deleage By: /s/ Alix Marduel ----------------------- ------------------------------- Jean Deleage, President Alix Marduel, Managing Director Alta BioPharma Management Partners, LLC Alta Embarcadero BioPharma Partners, LLC By: /s/ Alix Marduel By: /s/ Jean Deleage ----------------------- ------------------------------- Alix Marduel, Member Jean Deleage, Member Onyx Chase Partners (Alta Bio), LLC Alta/Chase BioPharma Management, LLC By: Alta/Chase BioPharma Management, LLC By: /s/ Alix Marduel By: /s/ Alix Marduel ----------------------- ------------------------------- Alix Marduel, Member Alix Marduel, Member /s/ Jean Deleage /s/ Guy Nohra ----------------------- ------------------------------- Jean Deleage Guy Nohra /s/ Garrett Gruener /s/ Marino Polestra ----------------------- ------------------------------- Garrett Gruener Marino Polestra /s/ Daniel Janney /s/ Alix Marduel ----------------------- ------------------------------- Daniel Janney Alix Marduel
Attachment A NO LONGER A 5% SHAREHOLDER IN ONYX PHARMACEUTICALS, INC. Alta Partners provides investment advisory services to several venture capital funds including, Alta BioPharma Partners L.P., Onyx Chase Partners (Alta Bio) LLC and Alta Embarcadero BioPharma Partners, LLC. Alta BioPharma Partners L.P. beneficially owns 423,369 shares of Common Stock. Onyx Chase Partners (Alta Bio) LLC beneficially owns 241,785 shares of Common Stock. Alta Embarcadero BioPharma Partners, LLC beneficially owns 15,957 shares of Common Stock. The respective general partner and managing members of Alta BioPharma Partners, L.P., Onyx Chase Partners (Alta Bio) LLC and Alta Embarcadero BioPharma Partners, LLC exercise sole voting and investment power with respect to the shares owned by such funds. On 8/18/00, 8/24/00 and 8/25/00: Alta BioPharma Partners, L.P. sold a total of 267,282 shares of Common Stock Onyx Chase Partners (Alta Bio) LLC sold a total of 152,643 shares of Common Stock. Alta Embarcadero BioPharma Partners, LLC sold a total of 10,075 shares of Common Stock. The principals of Alta Partners are members of Alta BioPharma Management, LLC (which is the general partner of Alta BioPharma Partners, L.P.), and Alta/Chase BioPharma Management LLC (which is the managing member of Onyx Chase Partners (Alta Bio), LLC) and Alta Embarcadero BioPharma Partners, LLC. As general partners and managing members of such entities, they may be deemed to share voting and investment powers for the shares held by the funds. The principals of Alta Partners disclaim beneficial ownership of all such shares held by the foregoing funds, except to the extent of their proportionate pecuniary interests therein. -----END PRIVACY-ENHANCED MESSAGE-----